Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 11/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8073739 | 0.93 | CNR2 (0.32) | EPHX1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8057648 | 0.92 | CYP1A2 (0.33) | EPHX1SMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL8068512 | 0.89 | SMN1; SMN2 (0.38) | EPHX1SMN1; SMN2EPHX2GNAI3GNAO1 | |
| Hydrochloric Acid SCHEMBL8071406 | 0.87 | CYP1A2 (0.35) | EPHX1SMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL8068006 | 0.85 | SMN1; SMN2 (0.32) | SMN1; SMN2CYP1A2 | |
| SCHEMBL8057813 | 0.82 | CNR2 (0.35) | SMN1; SMN2EPHX2GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL8068140 | 0.81 | SMN1; SMN2 (0.36) | SMN1; SMN2EPHX2GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL8069069 | 0.80 | MTNR1A (0.34) | EPHX1SMN1; SMN2EPHX2KMT2A | |
| SCHEMBL8066845 | 0.80 | CYP1A2 (0.32) | EPHX1SMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL8057530 | 0.78 | MTNR1A (0.33) | EPHX1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127496-A | POLYMERIZING OLEFINICALLY UNSATURATED COMPOUNDS IN PRESENCE OF METALLOCENE CATALYST SYSTEM CONTAINING A COMPOUND CAPABLE OF FORMING METALLOCENIUM IONS | BASF AKTIENGESELLSCHAFT (DE) | 2000-10-03 | — | — | US | disclosed |
| US-6077965-A | Metal complexes with an adamantane-like structure | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-20 | — | — | US | disclosed |