Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Acetylguanidinium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylguanidinium SCHEMBL79062 | 0.89 | — | — | |
| Acetylguanidinium SCHEMBL28322882 | 0.87 | — | — | |
| Acetylguanidinium SCHEMBL28647544 | 0.84 | CRBN (0.52) | CRBNTAS2R38LMNAALOX15BLM | |
| Acetylguanidinium SCHEMBL28298437 | 0.82 | CRBN (0.50) | CRBNTAS2R38LMNAALOX15BLM | |
| Biguanide SCHEMBL27297322 | 0.81 | CA4 (0.30) | — | |
| Acetylguanidinium SCHEMBL27551654 | 0.80 | CRBN (0.48) | CRBNTAS2R38LMNAALOX15BLM | |
| Phosphoric Acid SCHEMBL868319 | 0.79 | CRBN (0.39) | CRBNLMNABLMPMP22CA2 | |
| Phosphoric Acid SCHEMBL29143142 | 0.77 | CRBN (0.38) | CRBNLMNABLMPMP22CA2 | |
| Phosphoric Acid SCHEMBL9418072 | 0.75 | CRBN (0.36) | CRBNLMNABLMPMP22CA2 | |
| Phosphoric Acid SCHEMBL21177168 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684250-B1 | New poly(pentaerythrityl diphosphonate) and its use in self-extinguishing thermoplastic compositions | GREAT LAKES CHEMICAL ITALIA (IT) | 2000-09-27 | — | — | EP | claimed |
| US-5597855-A | FIREPROOFING | ENIRICERCHE S.P.A. (IT) | 1997-01-28 | — | — | US | claimed |
| EP-0684250-A1 | New poly(pentaerythrityl diphosphonate) and its use in self-extinguishing termoplastic compositions | GREAT LAKES CHEMICAL ITALIA S.r.l. (IT) | 1995-11-29 | — | — | EP | claimed |
| EP-0684250-B1 | New poly(pentaerythrityl diphosphonate) and its use in self-extinguishing thermoplastic compositions | GREAT LAKES CHEMICAL ITALIA (IT) | 2000-09-27 | — | — | EP | disclosed |
| US-5597855-A | FIREPROOFING | ENIRICERCHE S.P.A. (IT) | 1997-01-28 | — | — | US | disclosed |
| EP-0684250-A1 | New poly(pentaerythrityl diphosphonate) and its use in self-extinguishing termoplastic compositions | GREAT LAKES CHEMICAL ITALIA S.r.l. (IT) | 1995-11-29 | — | — | EP | disclosed |