Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | TACR2 | P21452 | 1/20 | 0.43 |
| ▸ | MC5R | P33032 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 3/20 | 0.43 |
| ▸ | FNTA | P49354 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 8/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5891488 | 0.90 | SCN9A (0.43) | RENSCN9AATMKMT2A | |
| SCHEMBL5891423 | 0.89 | FNTA (0.39) | EGFRFYNCHRM2CYP3A4ADRA2A | |
| SCHEMBL8079882 | 0.89 | FNTA (0.39) | EGFRFYNCHRM2CYP3A4ADRA2A | |
| SCHEMBL5891478 | 0.86 | EGFR (0.55) | EGFRFYNCHRM2CYP3A4ADRA2A | |
| SCHEMBL9182362 | 0.86 | EGFR (0.55) | EGFRFYNCHRM2CYP3A4ADRA2A | |
| SCHEMBL8075650 | 0.82 | CTRB1 (0.34) | FNTBFNTARENSCN9A | |
| SCHEMBL8075177 | 0.79 | KDM4E (0.34) | ALDH1A1RENSCN9A | |
| SCHEMBL8812949 | 0.78 | MEN1 (0.43) | ALDH1A1FNTBFNTAKMT2A | |
| SCHEMBL8075466 | 0.78 | SCN9A (0.33) | ALDH1A1RENSCN9A | |
| Hydrochloric Acid SCHEMBL5891922 | 0.78 | MEN1 (0.43) | EGFRFYNCHRM2CYP3A4ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0666844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |