Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | CRHBP | P24387 | 1/20 | 0.59 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.59 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 6/20 | 0.47 |
| ▸ | DRD3 | P35462 | 6/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10210997 | 0.93 | CHRNA7 (0.56) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL807400 | 0.83 | CHRNA7 (0.66) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL15084307 | 0.83 | CHRNA7 (0.66) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL807587 | 0.80 | CHRNA7 (0.61) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL15081976 | 0.80 | CHRNA7 (0.61) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL10210828 | 0.77 | CHRNA7 (0.97) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL15084319 | 0.77 | CHRNA7 (0.61) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL15081937 | 0.77 | CHRNA7 (0.57) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL807363 | 0.76 | CHRNA7 (1.00) | CHRNA7SMN1; SMN2CRHBPCRHR2DRD2 | |
| SCHEMBL13940586 | 0.76 | CHRNA7 (0.76) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |