Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | CRHBP | P24387 | 1/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.60 |
| ▸ | PDE2A | O00408 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 6/20 | 0.45 |
| ▸ | DRD4 | P21917 | 5/20 | 0.45 |
| ▸ | DRD3 | P35462 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15081976 | 1.00 | CHRNA7 (0.61) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL15081937 | 0.93 | CHRNA7 (0.57) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL15084307 | 0.84 | CHRNA7 (0.66) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL807400 | 0.84 | CHRNA7 (0.66) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL807180 | 0.81 | CHRNA7 (0.51) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL807391 | 0.80 | CHRNA7 (0.60) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A | |
| SCHEMBL15081975 | 0.79 | TSHR (0.66) | SMN1; SMN2PDE2AFAAHOPRM1OPRK1 | |
| SCHEMBL807183 | 0.79 | TSHR (0.66) | SMN1; SMN2PDE2AFAAHOPRM1OPRK1 | |
| SCHEMBL15081977 | 0.79 | TSHR (0.46) | SMN1; SMN2OPRM1OPRK1OPRL1 | |
| SCHEMBL10210828 | 0.78 | CHRNA7 (0.97) | CHRNA7SMN1; SMN2CRHBPCRHR2PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242981-B2 | Fused pyrazole derivatives as novel ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-26 | — | — | US | disclosed |
| US-20130172341-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MERCK SHARP & DOHME LLC | 2013-07-04 | — | — | US | disclosed |
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172341-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MAPK1, MAPK3, MAP3K1 | CHRNA7 4556/4885SMN1; SMN2 4597/4885CRHBP 4012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.