Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.66 |
| ▸ | CRHBP | P24387 | 1/20 | 0.64 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15084307 | 1.00 | CHRNA7 (0.66) | CHRNA7CRHBPCRHR2SMN1; SMN2PDE2A | |
| SCHEMBL15084319 | 0.92 | CHRNA7 (0.61) | CHRNA7CRHBPCRHR2SMN1; SMN2PDE2A | |
| SCHEMBL807587 | 0.84 | CHRNA7 (0.61) | CHRNA7CRHBPCRHR2SMN1; SMN2PDE2A | |
| SCHEMBL15081976 | 0.84 | CHRNA7 (0.61) | CHRNA7CRHBPCRHR2SMN1; SMN2PDE2A | |
| SCHEMBL15084357 | 0.83 | CHRNA7 (0.60) | CHRNA7CRHBPCRHR2SMN1; SMN2PDE2A | |
| SCHEMBL807391 | 0.83 | CHRNA7 (0.60) | CHRNA7CRHBPCRHR2SMN1; SMN2PDE2A | |
| SCHEMBL10210828 | 0.81 | CHRNA7 (0.97) | CHRNA7CRHBPCRHR2SMN1; SMN2PDE2A | |
| SCHEMBL807363 | 0.80 | CHRNA7 (1.00) | CHRNA7CRHBPCRHR2SMN1; SMN2LMNA | |
| SCHEMBL15081937 | 0.78 | CHRNA7 (0.57) | CHRNA7CRHBPCRHR2SMN1; SMN2PDE2A | |
| SCHEMBL10210997 | 0.77 | CHRNA7 (0.56) | CHRNA7CRHBPCRHR2SMN1; SMN2PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242981-B2 | Fused pyrazole derivatives as novel ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-26 | — | — | US | disclosed |
| US-20130172341-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MERCK SHARP & DOHME LLC | 2013-07-04 | — | — | US | disclosed |
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172341-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MAPK1, MAPK3, MAP3K1 | CHRNA7 4556/4885CRHBP 4012/4885CRHR2 4109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.