Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 16/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8073943 | 1.00 | OPRK1 (0.47) | OPRK1CYP2D6UTS2RCYP3A4OPRD1 | |
| SCHEMBL8081604 | 0.88 | OPRK1 (0.47) | OPRK1CYP2D6UTS2RCYP3A4OPRD1 | |
| SCHEMBL8081647 | 0.88 | OPRK1 (0.47) | OPRK1CYP2D6UTS2RCYP3A4OPRD1 | |
| SCHEMBL6977802 | 0.87 | OPRK1 (0.60) | OPRK1CYP2D6UTS2RCYP3A4OPRD1 | |
| SCHEMBL6977798 | 0.87 | OPRK1 (0.60) | OPRK1CYP2D6UTS2RCYP3A4OPRD1 | |
| SCHEMBL8074068 | 0.85 | OPRD1 (0.60) | OPRK1CYP2D6UTS2RCYP3A4OPRD1 | |
| SCHEMBL8074064 | 0.85 | OPRD1 (0.60) | OPRK1CYP2D6UTS2RCYP3A4OPRD1 | |
| SCHEMBL6978617 | 0.81 | OPRK1 (0.55) | OPRK1CYP2D6OPRD1OPRM1 | |
| SCHEMBL6978624 | 0.81 | OPRK1 (0.55) | OPRK1CYP2D6OPRD1OPRM1 | |
| SCHEMBL8081592 | 0.72 | OPRD1 (0.75) | OPRK1CYP2D6UTS2RCYP3A4OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789021-B1 | Hydroxamic acid compounds as opioid kappa receptor agonists | PFIZER (US) | 2000-10-11 | — | — | EP | claimed |
| EP-0789021-A1 | Hydroxamic acid compounds as opioid kappa receptor agonists | PFIZER INC. (US) | 1997-08-13 | — | — | EP | claimed |
| EP-0789021-B1 | Hydroxamic acid compounds as opioid kappa receptor agonists | PFIZER (US) | 2000-10-11 | — | — | EP | disclosed |
| US-5837717-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, ANTITUSSIVE AGENTS, DIURETICS, NEUROPROTECTIVE AGENTS; TREATING BOWEL DISEASE SUCH AS ABDOMINAL PAIN | PFIZER INC. (US) | 1998-11-17 | — | — | US | disclosed |
| EP-0789021-A1 | Hydroxamic acid compounds as opioid kappa receptor agonists | PFIZER INC. (US) | 1997-08-13 | — | — | EP | disclosed |