⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16691826 | 0.76 | KCNH2 (0.36) | — | |
| SCHEMBL12211683 | 0.72 | — | — | |
| SCHEMBL29960765 | 0.71 | TAAR1 (0.41) | — | |
| SCHEMBL15369209 | 0.71 | NPC1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL29960613 | 0.70 | TAAR1 (0.41) | — | |
| SCHEMBL10025872 | 0.70 | — | — | |
| SCHEMBL20017867 | 0.70 | — | — | |
| SCHEMBL13229261 | 0.69 | ADRA2A (0.34) | — | |
| SCHEMBL13233928 | 0.69 | TERT (0.33) | — | |
| SCHEMBL13234098 | 0.69 | KDM4C (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10251865-B2 | Method of activating regulatory T cells with alpha-2B adrenergic receptor agonists | ALLERGAN, INC. (US) | 2019-04-09 | — | — | US | disclosed |
| US-20180071259-A1 | METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS | ALLERGAN, INC. | 2018-03-15 | — | — | US | disclosed |
| US-20180071259-A1 | METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS | ALLERGAN, INC. | 2018-03-15 | — | — | US | disclosed |
| US-20170079956-A1 | METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS | ALLERGAN, INC. | 2017-03-23 | — | — | US | disclosed |
| US-20170079956-A1 | METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS | ALLERGAN, INC. | 2017-03-23 | — | — | US | disclosed |
| US-9545394-B2 | Method of activating regulatory T cells with alpha-2B adrenergic receptor agonists | ALLERGAN, INC. (US) | 2017-01-17 | — | — | US | disclosed |
| US-20160158199-A1 | METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS | ALLERGAN, INC. | 2016-06-09 | — | — | US | disclosed |
| US-9289420-B2 | Method of activating regulatory T cells with alpha-2B adrenergic receptor agonists | ALLERGAN, INC. (US) | 2016-03-22 | — | — | US | disclosed |
| US-20140066483-A1 | METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS | ALLERGAN, INC. (US) | 2014-03-06 | — | — | US | disclosed |
| US-8575207-B2 | Method of activating regulatory T cells with alpha-2B adrenergic receptor agonists | ALLERGAN, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| WO-2012024161-A1 | METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS | ALLERGAN, INC. (US) | 2012-02-23 | — | — | WO | disclosed |
| WO-2009020578-A1 | ALPHA2C ADRENORECEPTOR AGONISTS | SCHERING CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |