Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8073460 | 0.88 | CA1 (0.34) | CA1CA2CA7CTSSCTSK | |
| SCHEMBL8961031 | 0.83 | CTSS (0.40) | KDM4EALDH1A1HPGDNPSR1CTSS | |
| SCHEMBL5891488 | 0.83 | SCN9A (0.43) | KMT2A | |
| SCHEMBL4969118 | 0.83 | CTSS (0.50) | KDM4EALDH1A1HPGDNPSR1CA2 | |
| SCHEMBL9067533 | 0.82 | CTSS (0.35) | CTSSCTSKPSMB5 | |
| Hydrochloric Acid SCHEMBL8074695 | 0.79 | — | — | |
| SCHEMBL5891962 | 0.78 | FNTB (0.37) | ALDH1A1 | |
| SCHEMBL4973488 | 0.78 | CTSS (0.45) | KDM4EALDH1A1HPGDCA2CTSS | |
| SCHEMBL4970302 | 0.75 | CTSK (0.49) | CTSSCTSK | |
| SCHEMBL29097057 | 0.75 | CTSK (0.49) | CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0666844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |