Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797884 | 0.77 | GAA (0.47) | ATMLMNAGAAKDM4EHSD17B10 | |
| SCHEMBL797883 | 0.77 | GAA (0.47) | ATMLMNAGAAKDM4EHSD17B10 | |
| SCHEMBL27238712 | 0.77 | ATM (0.48) | ATMLMNAGAAKDM4EHSD17B10 | |
| SCHEMBL27238707 | 0.77 | ATM (0.48) | ATMLMNAGAAKDM4EHSD17B10 | |
| SCHEMBL19229780 | 0.75 | SMN1; SMN2 (0.51) | KDM4EALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29632582 | 0.74 | GAA (0.40) | ATMLMNAGAAKDM4EHSD17B10 | |
| SCHEMBL20908944 | 0.71 | LMNA (0.53) | ATMLMNAGAAKDM4EHSD17B10 | |
| SCHEMBL28543133 | 0.70 | KDM4E (0.50) | ATMLMNAGAAKDM4EHSD17B10 | |
| SCHEMBL26604074 | 0.68 | GAA (0.45) | ATMLMNAGAAKDM4EHSD17B10 | |
| SCHEMBL12156566 | 0.67 | KDM4E (0.53) | LMNAGAAKDM4ETDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |