Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797883 | 1.00 | GAA (0.47) | GAALMNAKDM4ETDP1HTT | |
| SCHEMBL20908944 | 0.90 | LMNA (0.53) | GAALMNAKDM4ETDP1HTT | |
| SCHEMBL20908946 | 0.84 | GAA (0.48) | GAALMNAKDM4ETDP1HTT | |
| SCHEMBL29632582 | 0.83 | GAA (0.40) | GAALMNAKDM4ETDP1HTT | |
| SCHEMBL807525 | 0.77 | ATM (0.48) | GAALMNAKDM4ETDP1HTT | |
| SCHEMBL29632685 | 0.76 | GRM2 (0.42) | GAALMNAKDM4ETDP1HTT | |
| SCHEMBL29632634 | 0.76 | HRH4 (0.47) | GAALMNAKDM4ETDP1HTT | |
| SCHEMBL22353526 | 0.75 | GAA (0.46) | GAALMNAKDM4ETDP1HTT | |
| SCHEMBL29632461 | 0.75 | GRM2 (0.46) | GAALMNAKDM4ETDP1HTT | |
| SCHEMBL29632580 | 0.75 | HRH4 (0.46) | GAALMNAKDM4ETDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |