Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 4/20 | 0.52 |
| ▸ | TERT | O14746 | 3/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.52 |
| ▸ | PPARD | Q03181 | 3/20 | 0.52 |
| ▸ | PPARA | Q07869 | 3/20 | 0.52 |
| ▸ | TOP1 | P11387 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | F7 | P08709 | 2/20 | 0.52 |
| ▸ | F3 | P13726 | 2/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863631 | 0.97 | LMNA (0.65) | LMNAMAPTABCC4TSHRNFKB1 | |
| SCHEMBL8671826 | 0.94 | LMNA (0.67) | LMNAMAPTABCC4TSHRNFKB1 | |
| SCHEMBL10971650 | 0.94 | LMNA (0.67) | LMNAMAPTABCC4TSHRNFKB1 | |
| SCHEMBL11583701 | 0.94 | LMNA (0.59) | LMNAMAPTABCC4TSHRNFKB1 | |
| SCHEMBL8459757 | 0.85 | GPR84 (0.73) | LMNAMAPTABCC4TSHRNFKB1 | |
| SCHEMBL7784335 | 0.85 | PPARG (0.73) | LMNAMAPTTSHRSLC22A6PPARG | |
| SCHEMBL7786847 | 0.85 | TOP1 (0.70) | LMNAMAPTTSHRSLC22A6PPARG | |
| SCHEMBL6391712 | 0.84 | LMNA (0.55) | LMNAMAPTABCC4TSHRNFKB1 | |
| SCHEMBL9400239 | 0.84 | CAMK2A (0.55) | LMNAMAPTABCC4TSHRNFKB1 | |
| SCHEMBL15367506 | 0.84 | F7 (0.77) | LMNAMAPTTSHRSLC22A6PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110957-A | ANTITUMOR AGENT TREATING CELL PROLIFERATIVE DISORDERS SUCH AS CANCER, DYES, FUNGICIDES, BACTERICIDES | SUGEN, INC. (US) | 2000-08-29 | — | — | US | disclosed |
| US-5786488-A | DEHYDROBROMINATION OF A DIBROMOBENZOQUINONES WITH AT LEAST ONE INDOLES IN A POLAR SOLVENT AND A METAL CARBONATE TO FORM AN ANTITUMOR AGENT | SUGEN, INC. (US) | 1998-07-28 | — | — | US | disclosed |