Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | TSHR | P16473 | 5/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.69 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.63 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.62 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.60 |
| ▸ | PPARG | P37231 | 7/20 | 0.60 |
| ▸ | PPARD | Q03181 | 7/20 | 0.60 |
| ▸ | PPARA | Q07869 | 7/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TLR2 | O60603 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | FABP4 | P15090 | 2/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.60 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.60 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sebacic Acid SCHEMBL28121390 | 0.97 | TSHR (0.75) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Decanoic Acid SCHEMBL22471653 | 0.87 | GPR84 (0.85) | LMNATSHRAKR1B1SLC22A6GPR84 | |
| Behenic Acid SCHEMBL28995864 | 0.87 | GPR84 (0.85) | LMNATSHRAKR1B1SLC22A6GPR84 | |
| Stearic Acid SCHEMBL28384522 | 0.87 | GPR84 (0.85) | LMNATSHRAKR1B1SLC22A6GPR84 | |
| Succinic Acid SCHEMBL209622 | 0.86 | EGLN1 (0.69) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Adipic Acid SCHEMBL11767551 | 0.86 | LMNA (0.85) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Adipic Acid SCHEMBL10388302 | 0.86 | LMNA (0.85) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Adipic Acid SCHEMBL8941691 | 0.86 | LMNA (1.00) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Adipic Acid SCHEMBL2244299 | 0.86 | LMNA (1.00) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Adipic Acid SCHEMBL1330953 | 0.86 | LMNA (1.00) | LMNATSHRNFKB1PMP22AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765891-B1 | Process for the preparation of water-blown integral skin polyurethane foams and catalysts useful therein | BAYER AG (US) | 2000-08-09 | — | — | EP | disclosed |
| EP-0765891-A1 | Water-blown integral skin polyurethane foams and catalysts useful therein | Bayer Corporation (US) | 1997-04-02 | — | — | EP | disclosed |
| US-5514723-A | POLYMERIZATION USING CATALYST MIXTURE OF DIORGANOTIN SULFIDE, TERTIARY AMINE, AND TIN COMPOUND | BAYER CORPORATION (US) | 1996-05-07 | — | — | US | disclosed |
| US-4855352-A | Process for the production of stable dispersions, the dispersions so produced, and the use thereof in the manufacture of polyurethanes | MOBAY CORPORATION (US) | 1989-08-08 | — | — | US | disclosed |
| US-4353995-A | TERTIARY AMINE, TIN COMPOUND, AND BARIUM OR CALCIUM CARBOXYLATE | MOBAY CHEMICAL CORPORATION (US) | 1982-10-12 | — | — | US | disclosed |
| EP-0016355-A2 | Novel catalyst system for polyurethane foams and the use thereof | Mobay Chemical Corporation (US) | 1980-10-01 | — | — | EP | disclosed |
| US-4217247-A | TERTIARY AMINE, TIN COMPOUND, CALCIUM OR BARIUM CARBOXYLATE | MOBAY CHEMICAL CORPORATION (US) | 1980-08-12 | — | — | US | disclosed |