Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 5/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279127 | 1.00 | TDP1 (0.56) | TDP1MEN1KMT2AFFAR1CA2 | |
| SCHEMBL2312474 | 1.00 | TDP1 (0.56) | TDP1MEN1KMT2AFFAR1CA2 | |
| SCHEMBL13992396 | 0.96 | TDP1 (0.56) | TDP1MEN1KMT2AFFAR1CA2 | |
| SCHEMBL12960557 | 0.96 | TDP1 (0.56) | TDP1MEN1KMT2AFFAR1CA2 | |
| SCHEMBL13992398 | 0.96 | TDP1 (0.56) | TDP1MEN1KMT2AFFAR1CA2 | |
| SCHEMBL14371523 | 0.94 | TDP1 (0.62) | TDP1MEN1KMT2AFFAR1CA2 | |
| SCHEMBL11119430 | 0.94 | TDP1 (0.62) | TDP1MEN1KMT2AFFAR1CA2 | |
| SCHEMBL21303703 | 0.87 | MEN1 (0.58) | TDP1MEN1KMT2ACA2KDM4E | |
| SCHEMBL12679110 | 0.86 | CA2 (0.45) | TDP1MEN1KMT2AFFAR1CA2 | |
| SCHEMBL8177188 | 0.86 | TDP1 (0.48) | TDP1MEN1KMT2AFFAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711289-B1 | PIPERAZINE COMPOUNDS USED IN THERAPY | DELTA PHARMACEUTICALS INC (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0710893-B1 | Charge transporting polymer, process for producing the same, and electrophotographic photoreceptor containing the same | FUJI XEROX CO LTD (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-5681830-A | DIARYLMETHYL PIPERAZINE COMPOUNDS HAVING UTILITY IN MEDICAL THERAPY AS RECEPTOR-BINDING SPECIES | DELTA PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| US-5639581-A | ELECTROPHOTOGRAPHIC PHOTORECEPTOR | FUJI XEROX CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| US-5574159-A | DIARYLMETHYL PIPERAZINES, RECEPTOR BINDING | DELTA PHARMACEUTICALS, INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5552404-A | COMPOUNDS FOR NEUROTRANSMITTERS FOR ANIMALS | DELTA PHARMACEUTICALS, INC. (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0711289-A1 | PIPERAZINE COMPOUNDS USED IN THERAPY | DELTA PHARMACEUTICALS, INC. (US) | 1996-05-15 | — | — | EP | disclosed |
| EP-0710893-A1 | Charge transporting polymer, process for producing the same, and organic electronic device containing the same | FUJI XEROX CO., LTD. (JP) | 1996-05-08 | — | — | EP | disclosed |
| WO-1996011927-A1 | ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-04-25 | — | — | WO | disclosed |
| US-5475106-A | Agonist for cholecystokinin and gastrin receptors; nervous system, gastrointestinal disorders | RHONE-POULENC RORER S.A. (FR) | 1995-12-12 | — | — | US | disclosed |
| WO-1995004051-A1 | PIPERAZINE COMPOUNDS USED IN THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |
| US-5382590-A | Gastrointestinal disorders and nervous system disorders | RHONE-POULENC RORER S.A. (FR) | 1995-01-17 | — | — | US | disclosed |