Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11279510 | 0.83 | CHRM3 (0.42) | PTPN1CES2CES1RAB9ASMN1; SMN2 | |
| SCHEMBL71405 | 0.83 | CYP2C9 (0.48) | PTPN1CES2CES1RAB9ASMN1; SMN2 | |
| SCHEMBL73485 | 0.81 | CHRM3 (0.41) | PTPN1CES2CES1RAB9ASMN1; SMN2 | |
| SCHEMBL71406 | 0.76 | KCNN4 (0.50) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL30230256 | 0.76 | CES1 (0.44) | PTPN1CES2CES1SMN1; SMN2KMT2A | |
| SCHEMBL2075002 | 0.75 | PTPN1 (0.42) | PTPN1CES2CES1RAB9ASMN1; SMN2 | |
| SCHEMBL11694973 | 0.74 | CES2 (0.44) | PTPN1CES2CES1RAB9ASMN1; SMN2 | |
| SCHEMBL3612581 | 0.71 | CFTR (0.42) | PTPN1KMT2AMEN1CHRM3MAPT | |
| SCHEMBL71754 | 0.71 | MAPT (0.42) | PTPN1CES2CES1RAB9AAGTR1 | |
| Bromomethane SCHEMBL6308629 | 0.70 | MAPT (0.42) | PTPN1CES2CES1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906351-B2 | 2,2′-furoin derivatives and use thereof to light skin | MERCK PATENT GMBH (DE) | 2014-12-09 | — | — | US | disclosed |
| US-8906351-B2 | 2,2′-furoin derivatives and use thereof to light skin | MERCK PATENT GMBH (DE) | 2014-12-09 | — | — | US | disclosed |
| US-8906351-B2 | 2,2′-furoin derivatives and use thereof to light skin | MERCK PATENT GMBH (DE) | 2014-12-09 | — | — | US | disclosed |
| EP-2616040-B1 | 2,2'-FUROIN DERIVATIVES AND THEIR USE FOR SKIN LIGHTENING | MERCK PATENT GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| EP-2616040-B1 | 2,2'-FUROIN DERIVATIVES AND THEIR USE FOR SKIN LIGHTENING | MERCK PATENT GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| US-20130164230-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHT SKIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-27 | — | — | US | disclosed |
| US-20130164230-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHT SKIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-27 | — | — | US | disclosed |
| US-20130164230-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHT SKIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-06-27 | — | — | US | disclosed |
| WO-2012034629-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHTEN SKIN | MERCK PATENT GMBH (DE) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130164230-A1 | 2,2'-FUROIN DERIVATIVES AND USE THEREOF TO LIGHT SKIN | TYR, ALDH1A2, MC1R | PTPN1 3033/4885CES2 3760/4885CES1 2523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.