SCHEMBL8077229

SCHEMBL8077229

C[Si](C)(C)NCC1CC2C=CC1C2

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.42
ALDH1A1 P00352 5/20 0.42
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
HTT P42858 1/20 0.35
TSHR P16473 1/20 0.34
LMNA P02545 1/20 0.32
TDP1 Q9NUW8 2/20 0.31
GAA P10253 1/20 0.31
IDO1 P14902 1/20 0.30
TDO2 P48775 1/20 0.30
EPHX2 P34913 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30716703 0.78 KDM4E (0.43) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL6935344 0.78 KDM4E (0.43) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL8165902 0.78 KDM4E (0.46) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL6355414 0.77 KDM4E (0.42) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL13346383 0.74 KDM4E (0.47) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL6036760 0.74 KDM4E (0.43) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL3649759 0.74 KDM4E (0.40) KDM4EALDH1A1TSHRLMNATDP1
SCHEMBL3645416 0.74 KDM4E (0.40) KDM4EALDH1A1TSHRLMNATDP1
SCHEMBL7072785 0.74 KDM4E (0.38) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL4816311 0.74 KDM4E (0.46) KDM4EALDH1A1MEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6166161-A Incorporation of functionalized comonomers in polyolefins THE DOW CHEMICAL COMPANY (US) 2000-12-26 US disclosed
WO-1997049738-A1 INCORPORATION OF FUNCTIONALIZED COMONOMERS IN POLYOLEFINS THE DOW CHEMICAL COMPANY (US) 1997-12-31 WO disclosed