Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.56 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 4/20 | 0.50 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004498 | 0.77 | TSHR (0.55) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL2850348 | 0.77 | TSHR (0.59) | TSHRLOXL2IDO1KCNJ1KCNH2 | |
| SCHEMBL18913824 | 0.77 | TSHR (0.69) | TSHRLOXL2IDO1KCNJ1KCNH2 | |
| SCHEMBL30758863 | 0.77 | TSHR (0.69) | TSHRLOXL2IDO1KCNJ1KCNH2 | |
| Sulfuric Acid SCHEMBL10890618 | 0.77 | F2 (0.53) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL3292782 | 0.77 | TSHR (0.75) | TSHRLOXL2IDO1KCNJ1KCNH2 | |
| SCHEMBL6821944 | 0.76 | TSHR (0.58) | TSHRLOXL2IDO1KCNJ1KCNH2 | |
| SCHEMBL530075 | 0.75 | TSHR (0.61) | TSHRLOXL2IDO1KCNJ1KCNH2 | |
| SCHEMBL43299 | 0.74 | LOXL2 (0.64) | TSHRLOXL2IDO1KCNJ1KCNH2 | |
| SCHEMBL1119530 | 0.74 | TSHR (0.60) | TSHRLOXL2IDO1KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882066-B1 | PEPTIDE DERIVATIVES | ZENECA LTD (GB) | 2000-09-06 | — | — | EP | disclosed |
| US-6087336-A | ANTIINFLAMMATORY AGENT TREATING RHEUMATOID ARTHRITIS | ZENECA LIMITED (GB) | 2000-07-11 | — | — | US | disclosed |
| EP-0882066-A1 | PEPTIDE DERIVATIVES | ZENECA LIMITED (GB) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997031023-A1 | PEPTIDE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-28 | — | — | WO | disclosed |