Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 5/20 | 0.80 |
| ▸ | SIRT2 | Q8IXJ6 | 13/20 | 0.79 |
| ▸ | SIRT1 | Q96EB6 | 13/20 | 0.79 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17737195 | 0.89 | SIRT5 (1.00) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL3952877 | 0.88 | SIRT2 (0.72) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL3952882 | 0.88 | SIRT2 (0.72) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL3953099 | 0.87 | SIRT2 (0.73) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL3953097 | 0.87 | SIRT2 (0.73) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL17742348 | 0.87 | SIRT5 (0.91) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL17737200 | 0.86 | SIRT2 (0.85) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL12877577 | 0.86 | SIRT5 (0.68) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL1160192 | 0.86 | SIRT5 (0.68) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL8076985 | 0.86 | SIRT5 (0.60) | SIRT5SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026701-A1 | SIRTUIN INHIBITORS | METHYLGENE INC. (CA) | 2009-03-05 | — | — | WO | disclosed |