Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | PRKCH | P24723 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807837 | 0.89 | PRKDC (0.38) | PIK3CAPIK3CBPRKDCATRATRIP | |
| SCHEMBL15133602 | 0.88 | MTOR (0.39) | GSK3BROCK2AURKBPIM1CLK1 | |
| SCHEMBL807975 | 0.81 | PRKDC (0.44) | PIK3CBPRKDCATRATRIPATM | |
| SCHEMBL807973 | 0.80 | ATM (0.41) | PIK3CAPIK3CBPRKDCATRATRIP | |
| SCHEMBL15133606 | 0.79 | MTOR (0.46) | ROCK2AURKBCLK4PRKCQROCK1 | |
| SCHEMBL1141996 | 0.78 | GSK3B (0.61) | GSK3BROCK2AURKBPIM1QPCT | |
| Hydrochloric Acid SCHEMBL1142046 | 0.76 | GSK3B (0.59) | GSK3BROCK2AURKBPIM1QPCT | |
| SCHEMBL10070634 | 0.75 | MAPT (0.41) | AURKBPIK3CAPIK3CBPRKDCATR | |
| SCHEMBL807826 | 0.71 | PI4KA (0.45) | PIK3CAPIK3CB | |
| SCHEMBL15131796 | 0.71 | MTOR (0.49) | AURKBCLK4PIK3CAPIK3CBPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034526-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-03-22 | — | — | WO | disclosed |