Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 12/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.40 |
| ▸ | PRKDC | P78527 | 11/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.40 |
| ▸ | ATR | Q13535 | 9/20 | 0.40 |
| ▸ | ATRIP | Q8WXE1 | 8/20 | 0.40 |
| ▸ | MTOR | P42345 | 6/20 | 0.38 |
| ▸ | SERPINA2 | P20848 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131796 | 0.87 | MTOR (0.49) | ATMNPBWR1PRKDCPIK3CBATR | |
| SCHEMBL807975 | 0.85 | PRKDC (0.44) | ATMPRKDCPIK3CBATRATRIP | |
| SCHEMBL10070634 | 0.83 | MAPT (0.41) | ATMPRKDCPIK3CBATRATRIP | |
| SCHEMBL807837 | 0.81 | PRKDC (0.38) | ATMPRKDCPIK3CBATRATRIP | |
| SCHEMBL807987 | 0.80 | GSK3B (0.38) | ATMPRKDCPIK3CBATRATRIP | |
| SCHEMBL807839 | 0.77 | PRKDC (0.43) | ATMPRKDCPIK3CBATRATRIP | |
| SCHEMBL15131811 | 0.76 | MTOR (0.38) | ATMPRKDCPIK3CBATRATRIP | |
| SCHEMBL15131800 | 0.75 | PIK3CB (0.42) | ATMPRKDCPIK3CBATRATRIP | |
| SCHEMBL807817 | 0.74 | PI4KA (0.52) | PIK3CBPIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL15133610 | 0.74 | PIK3CB (0.41) | ATMPRKDCPIK3CBATRATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034526-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-03-22 | — | — | WO | disclosed |