Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083145 | 0.88 | SRD5A2 (0.79) | SRD5A2MEN1PKMKMT2AALDH1A1 | |
| SCHEMBL8070858 | 0.83 | SRD5A2 (1.00) | SRD5A2MEN1PKMKMT2APLA2G4B | |
| SCHEMBL8435551 | 0.82 | SRD5A2 (0.70) | SRD5A2MEN1KMT2APTPN11PLA2G4B | |
| SCHEMBL6539987 | 0.82 | SRD5A2 (0.91) | SRD5A2MEN1PKMKMT2APLA2G4B | |
| SCHEMBL8084620 | 0.81 | SRD5A2 (1.00) | SRD5A2MEN1PKMKMT2APTPN11 | |
| SCHEMBL8078523 | 0.78 | SRD5A2 (1.00) | SRD5A2MEN1PKMKMT2AHCRTR1 | |
| SCHEMBL8079949 | 0.78 | SRD5A2 (1.00) | SRD5A2MEN1KMT2APTPN11RXRA | |
| SCHEMBL2997363 | 0.78 | SRD5A2 (0.63) | SRD5A2MEN1KMT2APTPN11HCRTR1 | |
| SCHEMBL8437505 | 0.77 | NR4A2 (0.62) | SRD5A2MEN1KMT2APLA2G4BHCRTR1 | |
| SCHEMBL8435714 | 0.76 | SRD5A2 (0.70) | SRD5A2MEN1PKMKMT2APLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | claimed |
| US-5965763-A | Biphenyl compounds | HOECHST MARION ROUSSEL (FR) | 1999-10-12 | — | — | US | disclosed |