Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 7/20 | 1.00 |
| ▸ | RARB | P10826 | 3/20 | 0.48 |
| ▸ | RARG | P13631 | 3/20 | 0.48 |
| ▸ | RARA | P10276 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 4/20 | 0.47 |
| ▸ | RXRB | P28702 | 4/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8079953 | 0.85 | SRD5A2 (0.74) | SRD5A2TSHRMEN1KMT2ABCHE | |
| SCHEMBL8070858 | 0.80 | SRD5A2 (1.00) | SRD5A2RARBMEN1KMT2A | |
| SCHEMBL8079904 | 0.78 | SRD5A2 (1.00) | SRD5A2RARBMEN1KMT2ARXRA | |
| SCHEMBL8437152 | 0.77 | SRD5A2 (0.62) | SRD5A2RARBRARGTSHRMEN1 | |
| SCHEMBL8435444 | 0.76 | SRD5A2 (0.61) | SRD5A2RARBRARGTSHRMEN1 | |
| SCHEMBL8079913 | 0.76 | SRD5A2 (1.00) | SRD5A2RARBMEN1KMT2ARXRA | |
| SCHEMBL6539987 | 0.75 | SRD5A2 (0.91) | SRD5A2MEN1KMT2ARXRARXRB | |
| SCHEMBL8435714 | 0.72 | SRD5A2 (0.70) | SRD5A2RARBTSHRMEN1KMT2A | |
| SCHEMBL25284690 | 0.72 | TSHR (0.68) | SRD5A2TSHR | |
| SCHEMBL8437183 | 0.71 | SRD5A2 (0.64) | SRD5A2RARBRARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | claimed |
| US-5965763-A | Biphenyl compounds | HOECHST MARION ROUSSEL (FR) | 1999-10-12 | — | — | US | disclosed |