Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | CTSS | P25774 | 5/20 | 0.44 |
| ▸ | CTSK | P43235 | 5/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205328 | 0.81 | KLK5 (0.57) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL10062432 | 0.81 | KLK5 (0.57) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL8079819 | 0.80 | KMT2A (0.39) | KLK5KMT2AATM | |
| SCHEMBL8065804 | 0.79 | PPARA (0.47) | PPARAKLK5PPARGCTSSCTSK | |
| SCHEMBL5891314 | 0.78 | ATM (0.48) | PPARAKLK5PPARGCTSSCTSK | |
| SCHEMBL9132420 | 0.74 | KLK5 (0.56) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL18493990 | 0.74 | SYK (0.73) | CTSSCTSKCTSLCTSBKMT2A | |
| SCHEMBL17340558 | 0.74 | SYK (0.73) | CTSSCTSKCTSLCTSBKMT2A | |
| SCHEMBL2723731 | 0.74 | SYK (0.73) | CTSSCTSKCTSLCTSBKMT2A | |
| SCHEMBL2723729 | 0.74 | SYK (0.73) | CTSSCTSKCTSLCTSBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0666844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |