Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 4/20 | 0.43 |
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072925 | 0.81 | KMT2A (0.40) | PPARAKLK5KMT2AATM | |
| SCHEMBL10062432 | 0.80 | KLK5 (0.57) | KLK5SYKCTSSCTSKCTSL | |
| SCHEMBL8205328 | 0.80 | KLK5 (0.57) | KLK5SYKCTSSCTSKCTSL | |
| SCHEMBL8079961 | 0.79 | PPARA (0.46) | PPARAPPARGKLK5SYKPPARD | |
| Hydrochloric Acid SCHEMBL8064981 | 0.76 | KIF11 (0.41) | — | |
| SCHEMBL9692628 | 0.74 | ATM (0.56) | KLK5SYKCTSSCTSKCTSL | |
| SCHEMBL9132420 | 0.74 | KLK5 (0.56) | KLK5SYKCTSSCTSKCTSL | |
| SCHEMBL18493990 | 0.73 | SYK (0.73) | SYKCTSSCTSKCTSLCTSB | |
| SCHEMBL17340558 | 0.73 | SYK (0.73) | SYKCTSSCTSKCTSLCTSB | |
| SCHEMBL2723729 | 0.73 | SYK (0.73) | SYKCTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666844-B1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1994010138-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |