Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | APAF1 | O14727 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | NOS1 | P29475 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | METAP2 | P50579 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | WEE1 | P30291 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737700 | 0.91 | NOS1 (0.52) | MAPTKDM4EMEN1KMT2AAPAF1 | |
| SCHEMBL22608972 | 0.83 | KDM4E (0.47) | MAPTKDM4EMEN1KMT2AAPAF1 | |
| SCHEMBL25964716 | 0.79 | FGFR1 (0.63) | MAPTKDM4EMEN1KMT2AAPAF1 | |
| SCHEMBL24365678 | 0.78 | MEN1 (0.49) | MAPTKDM4EMEN1KMT2AAPAF1 | |
| SCHEMBL12326069 | 0.78 | PRMT5 (0.52) | MAPTKDM4EMEN1KMT2AAPAF1 | |
| SCHEMBL4833473 | 0.77 | ROCK2 (0.52) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL7138051 | 0.77 | MAPT (0.42) | MAPTKDM4EMEN1KMT2AAPAF1 | |
| SCHEMBL9157501 | 0.73 | BACE1 (0.61) | MAPTKMT2ATDP1BACE1SLC6A4 | |
| SCHEMBL6837194 | 0.73 | KDM1A (0.70) | MAPTKDM4EMEN1KMT2AAPAF1 | |
| SCHEMBL15554029 | 0.72 | TLR9 (0.50) | MAPTKDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040829-A3 | Prokinetic agents for treating gastric hypomotility and related disorders | PFIZER INC. (US) | 2000-10-18 | — | — | EP | disclosed |
| EP-1040829-A2 | Prokinetic agents for treating gastric hypomotility and related disorders | PFIZER INC. (US) | 2000-10-04 | — | — | EP | disclosed |