SCHEMBL8080258

SCHEMBL8080258

CCC(C)OCc1c(Sc2ccccc2)[nH]c(=O)[nH]c1=O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.36
HPGD P15428 2/20 0.36
DHFR P00374 3/20 0.34
MAPT P10636 2/20 0.33
KDM4A O75164 1/20 0.33
KDM4C Q9H3R0 1/20 0.33
KDM4E B2RXH2 1/20 0.33
TYMP P19971 1/20 0.33
MEN1 O00255 1/20 0.33
GAA P10253 1/20 0.33
KMT2A Q03164 1/20 0.33
LMNA P02545 2/20 0.32
HTT P42858 2/20 0.32
GALR3 O60755 1/20 0.32
MTNR1A P48039 1/20 0.31
MTNR1B P49286 1/20 0.31
NR3C1 P04150 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
PTPN1 P18031 1/20 0.30
CDC25A P30304 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1443962 0.76 TYMP (0.46) ALDH1A1HPGDMAPTKDM4AKDM4C
SCHEMBL7070893 0.71 DHFR (0.47) ALDH1A1HPGDDHFRKDM4ETYMP
SCHEMBL7104065 0.69 KDM4E (0.39) ALDH1A1HPGDDHFRKDM4ETYMP
SCHEMBL9138375 0.67 TYMP (0.40) ALDH1A1HPGDMAPTKDM4AKDM4C
SCHEMBL6086721 0.64 TYMP (0.37) ALDH1A1HPGDDHFRKDM4ETYMP
SCHEMBL12549624 0.63 TSHR (0.46) ALDH1A1MAPTMEN1KMT2ATSHR
SCHEMBL14310474 0.63 TSHR (0.46) ALDH1A1MAPTMEN1KMT2ATSHR
SCHEMBL92279 0.63 TSHR (0.46) ALDH1A1MAPTMEN1KMT2ATSHR
SCHEMBL13258292 0.61 ALDH1A1 (0.50) ALDH1A1MAPTKDM4EMTNR1AMTNR1B
SCHEMBL9736034 0.61 IDO1 (0.34) ALDH1A1MAPTLMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6015820-A VIRICIDES; AIDS TREATMENT CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2000-01-18 US disclosed