Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8082188 | 0.93 | ALOX5 (0.49) | ALOX5ALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL8086701 | 0.89 | ALOX5 (0.46) | ALOX5MAOBCDK1CLK1DYRK1A | |
| SCHEMBL8072560 | 0.85 | MAOB (0.49) | ALOX5MAOBKDM4ENPC1HPGD | |
| SCHEMBL8081532 | 0.85 | ALOX5 (0.43) | ALOX5CDK1CLK1DYRK1ADYRK4 | |
| SCHEMBL8085182 | 0.80 | ALOX5 (0.49) | ALOX5ALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL8084895 | 0.79 | MAOB (0.53) | ALOX5MAOBMAOAGSTP1CDK4 | |
| SCHEMBL8085101 | 0.79 | ALOX5 (0.52) | ALOX5MAOBALDH1A1KDM4ENPC1 | |
| SCHEMBL8086720 | 0.73 | PDGFRB (0.51) | MAOBALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL8080534 | 0.72 | CDK1 (0.48) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL7286859 | 0.72 | GSTP1 (0.55) | MAOBALDH1A1KDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |