Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | WRN | Q14191 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 3/20 | 0.40 |
| ▸ | CCND1 | P24385 | 3/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8082188 | 0.92 | ALOX5 (0.49) | ALOX5CDK1CLK1DYRK1ADYRK4 | |
| SCHEMBL8080372 | 0.89 | ALOX5 (0.46) | ALOX5CDK1CLK1DYRK1ADYRK4 | |
| SCHEMBL8072560 | 0.87 | MAOB (0.49) | ALOX5CDK1CLK1DYRK1ADYRK4 | |
| SCHEMBL8081532 | 0.87 | ALOX5 (0.43) | ALOX5CDK1CLK1DYRK1ADYRK4 | |
| SCHEMBL8085131 | 0.80 | ALOX5 (0.51) | ALOX5CDK1CLK1DYRK1ADYRK4 | |
| SCHEMBL8085182 | 0.79 | ALOX5 (0.49) | ALOX5KMT2A | |
| SCHEMBL8467441 | 0.79 | PDGFRB (0.47) | PDGFRBMAOBKMT2ACDK4CCND1 | |
| SCHEMBL8084895 | 0.78 | MAOB (0.53) | ALOX5MAOBGSTP1CDK4CCND1 | |
| SCHEMBL8148248 | 0.72 | ALOX5 (0.52) | ALOX5DYRK1AKMT2AGSK3BCHEK1 | |
| SCHEMBL8080534 | 0.72 | CDK1 (0.48) | CDK1CLK1DYRK1ADYRK4PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |
| EP-0920416-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007705-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-26 | — | — | WO | disclosed |