Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085040 | 0.88 | CDK2 (0.39) | ALDH1A1CDK2CHEK1WEE1AURKA | |
| SCHEMBL2959109 | 0.85 | ALOX5 (0.48) | CDK2ALOX5MEN1KMT2A | |
| SCHEMBL8080585 | 0.83 | ALOX5 (0.53) | ALDH1A1HPGDNR3C2CDK2L3MBTL1 | |
| SCHEMBL8072614 | 0.82 | CHEK1 (0.40) | CDK2CHEK1WEE1GAAAURKA | |
| SCHEMBL8086819 | 0.81 | CDK2 (0.39) | CDK2CHEK1WEE1AURKACDK1 | |
| SCHEMBL8082093 | 0.81 | CDK2 (0.39) | CDK2AURKACDK1CDK4HSP90AA1 | |
| SCHEMBL8084885 | 0.81 | PTGS2 (0.44) | NR3C2CDK2CHEK1WEE1AURKA | |
| SCHEMBL2960392 | 0.81 | TOP2A (0.48) | ALDH1A1HPGDCDK2L3MBTL1CDK4 | |
| SCHEMBL8080517 | 0.80 | APP (0.41) | ALDH1A1HPGDCDK2CHEK1WEE1 | |
| SCHEMBL8072321 | 0.79 | CDK2 (0.43) | ALDH1A1HPGDCDK2AURKACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |