Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 9/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083071 | 0.78 | MAPT (0.40) | TSHRLMNANPSR1KMT2AUSP2 | |
| SCHEMBL8081073 | 0.74 | TSHR (0.43) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9025866 | 0.68 | LMNA (0.67) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7346517 | 0.68 | TSHR (0.39) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8536251 | 0.67 | TSHR (0.59) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8535859 | 0.67 | TSHR (0.55) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11818792 | 0.66 | LMNA (0.46) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8078203 | 0.65 | GRIA1 (0.44) | PDE5ACD38 | |
| SCHEMBL8538423 | 0.65 | TSHR (0.52) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8535868 | 0.65 | TSHR (0.49) | TSHRMAPK1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025489-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |
| EP-0429149-B1 | Tricyclic pteridinones and a process for their preparation | BERLEX LAB (US) | 2000-01-05 | — | — | EP | disclosed |
| US-5854419-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-29 | — | — | US | disclosed |
| US-5602252-A | Tricyclic pteridinones and a process for their preparation | BERLEX LABORATORIES, INC. | 1997-02-11 | — | — | US | disclosed |
| EP-0429149-A1 | Tricyclic pteridinones and a process for their preparation | BERLEX LABORATORIES, INC. (US) | 1991-05-29 | — | — | EP | disclosed |