Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081075 | 0.78 | TSHR (0.40) | MAPTALDH1A1HTTPDE5ACYP19A1 | |
| SCHEMBL8083067 | 0.77 | MAPT (0.41) | MAPTMITFALDH1A1HTTGRIA1 | |
| SCHEMBL7345941 | 0.69 | GRIA1 (0.44) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL1693744 | 0.69 | MAPT (0.38) | MAPTMITFALDH1A1HTTGRIA1 | |
| SCHEMBL7046842 | 0.65 | MAPK1 (0.48) | MAPTALDH1A1NPSR1 | |
| SCHEMBL6699244 | 0.65 | MAPT (0.38) | MAPTMITFALDH1A1HTTGRIA1 | |
| SCHEMBL9025866 | 0.63 | LMNA (0.67) | MAPTHTTPDE5ACYP19A1KMT2A | |
| SCHEMBL6702558 | 0.63 | PDE5A (0.42) | MAPTMITFALDH1A1HTTGRIA1 | |
| SCHEMBL8078203 | 0.63 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL28747262 | 0.62 | NPSR1 (0.35) | MAPTMITFALDH1A1HTTGRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025489-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |
| EP-0429149-B1 | Tricyclic pteridinones and a process for their preparation | BERLEX LAB (US) | 2000-01-05 | — | — | EP | disclosed |
| US-5854419-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-29 | — | — | US | disclosed |
| US-5602252-A | Tricyclic pteridinones and a process for their preparation | BERLEX LABORATORIES, INC. | 1997-02-11 | — | — | US | disclosed |