SCHEMBL808171

SCHEMBL808171

CC(C)(C)OC(=O)NCc1ccc(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(C(F)(F)F)C2CO)cc1Cl

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.37
TRPV1 Q8NER1 1/20 0.35
P2RY14 Q15391 1/20 0.34
DRD2 P14416 5/20 0.34
KCNH2 Q12809 2/20 0.34
MCHR1 Q99705 2/20 0.34
CACNA1H O95180 1/20 0.33
CACNA1B Q00975 1/20 0.33
CACNA1C Q13936 1/20 0.33
TACR1 P25103 2/20 0.33
P2RX7 Q99572 1/20 0.33
EPHX2 P34913 4/20 0.33
NR1H4 Q96RI1 2/20 0.33
IDO1 P14902 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL807583 0.91 ALDH1A1 (0.38) ALDH1A1TRPV1P2RY14DRD2KCNH2
SCHEMBL808170 0.81
SCHEMBL794922 0.79 KCNH2 (0.37) KCNH2MCHR1P2RX7EPHX2NR1H4
SCHEMBL807597 0.79 ALDH1A1 (0.37) ALDH1A1TRPV1DRD2KCNH2MCHR1
SCHEMBL795181 0.77 CACNA1H (0.39) TRPV1P2RY14CACNA1HCACNA1BCACNA1C
SCHEMBL807608 0.77 KCNH2 (0.46) ALDH1A1KCNH2MCHR1P2RX7EPHX2
SCHEMBL794992 0.77 KCNH2 (0.46) ALDH1A1KCNH2MCHR1P2RX7EPHX2
SCHEMBL794562 0.71 AR (0.31)
SCHEMBL15466506 0.67 EPHX2 (0.42) TRPV1KCNH2MCHR1P2RX7EPHX2
SCHEMBL17874869 0.67 EPHX2 (0.39) TRPV1DRD2CACNA1HCACNA1BCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012035011-A1 PESTICIDAL ARYLPYRROLIDINES BAYER CROPSCIENCE AG (DE) 2012-03-22 WO disclosed