Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL20478 | 1.00 | — | — | |
| Propylene Glycol SCHEMBL8072957 | 1.00 | TDP1 (0.77) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL28302926 | 1.00 | TDP1 (0.77) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL27529046 | 0.96 | — | — | |
| Propylene Glycol SCHEMBL28321892 | 0.93 | TDP1 (0.67) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL560576 | 0.93 | TDP1 (0.67) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Glycerin SCHEMBL22441083 | 0.90 | TDP1 (0.62) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL29008558 | 0.90 | TDP1 (0.62) | TDP1TSHRALDH1A1LMNAMAPK1 | |
| Propylene Glycol SCHEMBL19514495 | 0.89 | — | — | |
| Propylene Glycol SCHEMBL3535 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6126733-A | ALKOXY SILANE, A LOW VOLATILITY ALKYLENE GLYCOL ALKYL ETHER OF GIVEN HYDROXYL CONCENTRATION, AND BOILING POINT; HIGHER VOLATILITY SOLVENT OF LOWER BOILING POINT THAN THE LOW VOLATILITY SOLVENT AND OPTIONALLY WATER AND ACID CATALYST | ALLIEDSIGNAL INC. (US) | 2000-10-03 | — | — | US | disclosed |