Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093344 | 0.91 | PIK3CD (0.40) | PIK3CDKDRPIK3CAMTORPIK3CG | |
| SCHEMBL8096016 | 0.87 | PIK3CD (0.43) | PIK3CDKDRPIK3CAMTORPIK3CG | |
| SCHEMBL8106273 | 0.87 | PIK3CD (0.43) | PIK3CDKDRPIK3CAMTORPIK3CG | |
| SCHEMBL8088889 | 0.86 | PIK3CD (0.44) | PIK3CDKDRPIK3CAMTORPIK3CG | |
| SCHEMBL8099345 | 0.86 | PIK3CD (0.44) | PIK3CDKDRPIK3CAMTORPIK3CG | |
| SCHEMBL8084009 | 0.86 | PIK3CD (0.42) | PIK3CDPIK3CAMTORPIK3CGPIK3CB | |
| SCHEMBL8092385 | 0.85 | PIK3CD (0.41) | PIK3CDKDRPIK3CAMTORPIK3CG | |
| SCHEMBL8090864 | 0.85 | PIK3CD (0.47) | PIK3CDPIK3CAMTORPIK3CGPIK3CB | |
| SCHEMBL8083655 | 0.85 | NAMPT (0.43) | PIK3CDKDRPIK3CAMEN1KMT2A | |
| SCHEMBL8097652 | 0.84 | PIK3CD (0.38) | PIK3CDKDRPIK3CAMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |