Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 3/20 | 0.56 |
| ▸ | CTSS | P25774 | 3/20 | 0.54 |
| ▸ | CTSK | P43235 | 2/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | ACE | P12821 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24872320 | 0.90 | BCL2 (0.55) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL12907929 | 0.90 | ATM (0.45) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL3289149 | 0.88 | ATM (0.50) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL5780237 | 0.88 | ATM (0.50) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL27533342 | 0.88 | ATM (0.50) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL1104909 | 0.87 | ATM (0.54) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL4974304 | 0.87 | ATM (0.54) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL5865405 | 0.87 | ATM (0.54) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL2079109 | 0.87 | ATM (0.54) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL7438571 | 0.87 | ATM (0.54) | ATMCTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346877-B1 | PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B]FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL](ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | JANSSEN R & D IRELAND (IE) | 2014-08-20 | — | — | EP | disclosed |
| US-8163933-B2 | Clean, high-yield preparation of S,S and R,S amino acid isosteres | AMPAC FINE CHEMICALS LLC (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2152667-B1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | TIBOTEC PHARM LTD (IE) | 2011-02-16 | — | — | EP | disclosed |
| US-20100305073-A1 | AMIDE COMPOUNDS AS BOOSTERS OF ANTIVIRALS | TIBOTEC BVBA | 2010-12-02 | — | — | US | disclosed |
| US-20100121094-A1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | TIBOTEC PHARMACEUTICALS LTD | 2010-05-13 | — | — | US | disclosed |
| WO-2008132154-A1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-11-06 | — | — | WO | disclosed |
| WO-2006032999-A1 | N-METHYL HYDROXYETHYLAMINE USEFUL IN TREATING CNS CONDITIONS | PFIZER PRODUCTS INC. (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305073-A1 | AMIDE COMPOUNDS AS BOOSTERS OF ANTIVIRALS | CYP3A5, CYP3A4, CYP3A43 | ATM 4586/4885CTSS 273/4885CTSK 1352/4885 |
| US-20100121094-A1 | METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES | DNPEP, NPEPPS, ASNS | ATM 4096/4885CTSS 732/4885CTSK 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.