Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.74 |
| ▸ | FLT1 | P17948 | 5/20 | 0.58 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7537238 | 0.86 | EGFR (0.67) | EGFRFLT1ERBB2KDRRET | |
| SCHEMBL8093519 | 0.85 | EGFR (1.00) | EGFRFLT1ERBB2 | |
| SCHEMBL7535216 | 0.82 | EGFR (0.65) | EGFRFLT1ERBB2KDRRET | |
| SCHEMBL7021509 | 0.81 | EGFR (0.70) | EGFRFLT1KDR | |
| SCHEMBL7541823 | 0.80 | EGFR (0.60) | EGFRFLT1ERBB2KDRRET | |
| SCHEMBL3606262 | 0.80 | EGFR (0.73) | EGFRFLT1ERBB2KDR | |
| Hydrochloric Acid SCHEMBL7020471 | 0.80 | EGFR (0.69) | EGFRFLT1KDR | |
| SCHEMBL1733829 | 0.80 | EGFR (0.76) | EGFRFLT1ERBB2KDRRET | |
| SCHEMBL31514622 | 0.80 | EGFR (0.69) | EGFRFLT1ERBB2KDRRET | |
| SCHEMBL27545981 | 0.80 | EGFR (0.69) | EGFRFLT1ERBB2KDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | claimed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |