Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.31 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.31 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.31 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068200 | 0.83 | FAAH (0.35) | FAAHDPP7GNAI3GNAO1GNAI1 | |
| SCHEMBL8075652 | 0.74 | DPP7 (0.34) | FAAHDPP7GNAI3GNAO1GNAI1 | |
| SCHEMBL8077588 | 0.74 | DPP7 (0.34) | FAAHDPP7GNAI3GNAO1GNAI1 | |
| SCHEMBL14090886 | 0.72 | DPP7 (0.44) | DPP7GNAI3GNAO1GNAI1MAPK1 | |
| SCHEMBL7974902 | 0.72 | DPP7 (0.44) | DPP7GNAI3GNAO1GNAI1MAPK1 | |
| SCHEMBL8082176 | 0.71 | DPP7 (0.42) | DPP7GNAI3GNAO1GNAI1MAPK1 | |
| SCHEMBL7911960 | 0.71 | DPP7 (0.42) | DPP7GNAI3GNAO1GNAI1MAPK1 | |
| SCHEMBL8077572 | 0.71 | FOLH1 (0.36) | DPP7GNAI3GNAO1GNAI1MAPK1 | |
| SCHEMBL8075669 | 0.71 | FOLH1 (0.36) | DPP7GNAI3GNAO1GNAI1MAPK1 | |
| SCHEMBL8077675 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749418-A1 | L-N6 -(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-12-27 | — | — | EP | claimed |
| WO-1995024382-A1 | L-N6-(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-09-14 | — | — | WO | claimed |
| US-6143790-A | ENZYME INHIBITORS | G.D. SEARLE & CO. (US) | 2000-11-07 | — | — | US | disclosed |
| EP-0749418-B1 | L-N6 -(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-08-30 | — | — | EP | disclosed |
| EP-0749418-A1 | L-N6 -(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995024382-A1 | L-N6-(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-09-14 | — | — | WO | disclosed |