Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 5/20 | 0.43 |
| ▸ | F10 | P00742 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8075751 | 0.86 | NOS3 (0.50) | NOS3NOS1NOS2F10PRSS1 | |
| SCHEMBL1162624 | 0.86 | NOS3 (0.50) | NOS3NOS1NOS2F10PRSS1 | |
| SCHEMBL9017525 | 0.83 | NOS3 (0.39) | NOS3NOS1NOS2SLC7A5F2 | |
| SCHEMBL8082410 | 0.81 | SLC7A5 (0.43) | NOS3NOS1NOS2SLC7A5F2 | |
| SCHEMBL20715034 | 0.80 | NOS3 (0.59) | NOS3NOS1NOS2SLC7A5SLC1A2 | |
| SCHEMBL27999753 | 0.79 | ITGB3 (0.50) | NOS3NOS1NOS2ANPEPENPEP | |
| SCHEMBL289140 | 0.79 | ITGB3 (0.50) | NOS3NOS1NOS2ANPEPENPEP | |
| SCHEMBL24704906 | 0.78 | SLC7A5 (0.50) | SLC7A5ANPEPENPEPLMNAPARP10 | |
| SCHEMBL287831 | 0.78 | NOS3 (0.70) | NOS3NOS1NOS2SLC7A5ITGB3 | |
| SCHEMBL22255875 | 0.78 | SLC7A5 (0.50) | SLC7A5ANPEPENPEPLMNAPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143790-A | ENZYME INHIBITORS | G.D. SEARLE & CO. (US) | 2000-11-07 | — | — | US | disclosed |
| EP-0749418-B1 | L-N6 -(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-08-30 | — | — | EP | disclosed |
| WO-1995024382-A1 | L-N6-(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-09-14 | — | — | WO | disclosed |