Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 4/20 | 0.39 |
| ▸ | NOS1 | P29475 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8079624 | 0.98 | NOS2 (0.46) | NOS2HTTALDH1A1GRIN2DGRIN3B | |
| SCHEMBL22180009 | 0.81 | NOS2 (0.46) | NOS2HTTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6682638 | 0.81 | NOS2 (0.46) | NOS2HTTALDH1A1GRIN2DGRIN3B | |
| SCHEMBL7020087 | 0.80 | NOS2 (0.70) | NOS2ALDH1A1NOS3KDM4EHIF1A | |
| SCHEMBL6682071 | 0.77 | NOS2 (0.46) | NOS2HTTALDH1A1GRIN2DGRIN3B | |
| SCHEMBL20487491 | 0.76 | CA12 (0.48) | NOS2HTTALDH1A1SMN1; SMN2NOS1 | |
| Hydrochloric Acid SCHEMBL7327781 | 0.75 | CA12 (0.47) | NOS2HTTALDH1A1SMN1; SMN2NOS1 | |
| SCHEMBL5955 | 0.70 | MAPT (0.53) | NOS2HTTALDH1A1SMN1; SMN2NOS3 | |
| SCHEMBL56667 | 0.69 | NOS3 (0.50) | HTTALDH1A1NOS3NOS1MAPT | |
| SCHEMBL12122146 | 0.69 | NOS3 (0.50) | HTTALDH1A1NOS3NOS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882066-B1 | PEPTIDE DERIVATIVES | ZENECA LTD (GB) | 2000-09-06 | — | — | EP | disclosed |
| US-6087336-A | ANTIINFLAMMATORY AGENT TREATING RHEUMATOID ARTHRITIS | ZENECA LIMITED (GB) | 2000-07-11 | — | — | US | disclosed |
| EP-0882066-A1 | PEPTIDE DERIVATIVES | ZENECA LIMITED (GB) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997031023-A1 | PEPTIDE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-28 | — | — | WO | disclosed |