Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.44 |
| ▸ | MTOR | P42345 | 17/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15133597 | 0.94 | PIK3CA (0.46) | PIK3CAMTOR | |
| SCHEMBL15131851 | 0.91 | PIK3CA (0.47) | PIK3CAMTOR | |
| SCHEMBL808263 | 0.89 | GRIN2B (0.41) | PIK3CAMTORGRIN2BTMEM97 | |
| SCHEMBL10070215 | 0.88 | MTOR (0.54) | PIK3CAMTOR | |
| SCHEMBL10070214 | 0.87 | MTOR (0.54) | PIK3CAMTORUSP2 | |
| SCHEMBL808098 | 0.87 | MTOR (0.47) | PIK3CAMTORUSP2 | |
| SCHEMBL808111 | 0.86 | MTOR (0.51) | PIK3CAMTOR | |
| SCHEMBL10070234 | 0.85 | MTOR (0.44) | PIK3CAMTOR | |
| SCHEMBL15123601 | 0.85 | PIK3CA (0.46) | PIK3CAMTOR | |
| SCHEMBL808273 | 0.84 | MTOR (0.53) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181264-B2 | Fused heteroaryls and their uses | HUTCHISON MEDIPHARMA LIMITED (CN) | 2015-11-10 | — | — | US | disclosed |
| US-20130190307-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-07-25 | — | — | US | disclosed |
| WO-2012034526-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190307-A1 | FUSED HETEROARYLS AND THEIR USES | FARS2, TIAL1, DHFR | PIK3CA 1962/4885MTOR 4193/4885USP2 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.