Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.47 |
| ▸ | MTOR | P42345 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL944808 | 0.89 | PIK3CA (0.49) | PIK3CAPIK3R1HDAC1MTORHDAC3 | |
| SCHEMBL12910204 | 0.88 | PIK3CA (0.44) | PIK3CAPIK3R1HDAC1MTORPIK3CG | |
| SCHEMBL12910202 | 0.86 | ATR (0.48) | PIK3CAPIK3R1HDAC1MTORPIK3CG | |
| SCHEMBL1568565 | 0.85 | PIK3CA (0.53) | PIK3CAPIK3R1HDAC1MTORHDAC3 | |
| SCHEMBL12910182 | 0.85 | PDE10A (0.48) | PIK3CAPIK3R1HDAC1MTORPIK3CG | |
| SCHEMBL12910205 | 0.85 | PIK3CA (0.47) | PIK3CAPIK3R1HDAC1HDAC3HDAC4 | |
| SCHEMBL1569308 | 0.82 | PIK3CA (0.57) | PIK3CAPIK3R1HDAC1MTORPIK3CG | |
| SCHEMBL1570938 | 0.82 | PIK3CA (0.59) | PIK3CAPIK3R1HDAC1MTORHDAC3 | |
| SCHEMBL12910556 | 0.82 | CSNK1E (0.44) | PIK3CAHDAC1MTORHDAC3HDAC4 | |
| SCHEMBL12910192 | 0.80 | ALDH1A1 (0.49) | PIK3CAHDAC1HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009045174-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD (SG) | 2009-04-09 | — | — | WO | disclosed |