Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | CASP1 | P29466 | 6/20 | 0.43 |
| ▸ | CASP7 | P55210 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.43 |
| ▸ | USP2 | O75604 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083480 | 0.89 | PIK3CA (0.48) | PIK3CAPIK3R1MTORHDAC1HDAC3 | |
| SCHEMBL12910204 | 0.86 | PIK3CA (0.44) | PIK3CAPIK3R1MTORHDAC1HDAC3 | |
| SCHEMBL12910205 | 0.85 | PIK3CA (0.47) | PIK3CAPIK3R1HDAC1HDAC3HDAC4 | |
| SCHEMBL12910202 | 0.84 | ATR (0.48) | PIK3CAPIK3R1MTORHDAC1HDAC3 | |
| SCHEMBL12910182 | 0.84 | PDE10A (0.48) | PIK3CAPIK3R1MTORHDAC1KMT2A | |
| SCHEMBL12910192 | 0.83 | ALDH1A1 (0.49) | PIK3CAHDAC1CYP1A2TSHRALDH1A1 | |
| SCHEMBL12945576 | 0.83 | PIK3CA (0.56) | PIK3CAMTOR | |
| SCHEMBL944764 | 0.83 | PIK3CA (0.60) | PIK3CAMTORHDAC1CYP1A2ALDH1A1 | |
| SCHEMBL12910556 | 0.82 | CSNK1E (0.44) | PIK3CAMTORHDAC1HDAC3HDAC4 | |
| SCHEMBL946795 | 0.82 | KDR (0.41) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD. (SG) | 2011-01-13 | — | — | US | disclosed |
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD. (SG) | 2011-01-13 | — | — | US | disclosed |
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD. (SG) | 2011-01-13 | — | — | US | disclosed |
| EP-2209785-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO Pte Ltd (SG) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009045174-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD (SG) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | PIK3CA, TPMT, MTOR | PIK3CA 1/4885PIK3R1 36/4885MTOR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.