SCHEMBL8083703

SCHEMBL8083703

N#CC(C#N)c1ccccc1OC(=O)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 6/20 0.53
▸ MAPT P10636 3/20 0.53
▸ SMN1; SMN2 Q16637 3/20 0.53
▸ SLC6A3 Q01959 1/20 0.47
▸ ESR1 P03372 2/20 0.46
▸ ESR2 Q92731 2/20 0.46
▸ HSD17B10 Q99714 2/20 0.46
▸ GAA P10253 2/20 0.46
▸ MEN1 O00255 1/20 0.46
▸ JAK2 O60674 1/20 0.46
▸ USP2 O75604 1/20 0.46
▸ ALOX15 P16050 1/20 0.46
▸ NPSR1 Q6W5P4 1/20 0.46
▸ LMNA P02545 3/20 0.43
▸ METAP2 P50579 1/20 0.43
▸ METAP1 P53582 1/20 0.43
▸ HDAC6 Q9UBN7 1/20 0.43
▸ TOP1 P11387 1/20 0.43
▸ PARP1 P09874 1/20 0.41
▸ POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26490327 0.77 KMT2A (0.56) KMT2AMAPTSMN1; SMN2SLC6A3ESR1
SCHEMBL725404 0.76 KMT2A (0.76) KMT2AMAPTSMN1; SMN2SLC6A3ESR1
SCHEMBL31517375 0.75 KMT2A (0.68) KMT2AMAPTSMN1; SMN2SLC6A3ESR1
SCHEMBL6567956 0.75 KMT2A (0.58) KMT2AMAPTSMN1; SMN2SLC6A3ESR1
Hydrochloric Acid SCHEMBL16050041 0.74 KMT2A (0.73) KMT2AMAPTSMN1; SMN2SLC6A3ESR1
Bromide SCHEMBL29588519 0.74 KMT2A (0.73) KMT2AMAPTSMN1; SMN2SLC6A3ESR1
SCHEMBL20592356 0.74 KMT2A (0.53) KMT2AMAPTSMN1; SMN2SLC6A3ESR1
SCHEMBL6967920 0.73 KMT2A (0.66) KMT2AMAPTSMN1; SMN2SLC6A3ESR1
SCHEMBL11374397 0.72 NPSR1 (0.54) KMT2AMAPTSMN1; SMN2SLC6A3ESR1
SCHEMBL27779470 0.72 KMT2A (0.63) KMT2AMAPTSMN1; SMN2SLC6A3ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 — — EP claimed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 — — EP claimed
EP-0743574-A2 Migration imaging members XEROX CORPORATION (US) 1996-11-20 — — EP claimed
EP-0743573-A2 Method for obtaining image contrast migration imaging members XEROX CORPORATION (US) 1996-11-20 — — EP claimed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 — — US claimed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 — — US claimed
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 — — EP disclosed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 — — US disclosed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 — — US disclosed
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