Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.53 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6227149 | 0.87 | HRH3 (0.59) | HRH3KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL6227147 | 0.87 | HRH3 (0.59) | HRH3KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL6226795 | 0.86 | HRH3 (0.61) | HRH3KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL6226793 | 0.86 | HRH3 (0.61) | HRH3KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL7847689 | 0.82 | HRH3 (0.53) | HRH3NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL8534713 | 0.81 | HRH3 (0.57) | HRH3NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL8534716 | 0.81 | HRH3 (0.57) | HRH3NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL3022632 | 0.78 | HRH3 (0.57) | HRH3SMN1; SMN2KDM4EKMT2ATEAD1 | |
| SCHEMBL28842288 | 0.77 | HRH3 (0.52) | HRH3NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL8587005 | 0.76 | HRH3 (0.48) | HRH3NOS3NOS1NOS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045832-A2 | NOVEL URETHANES, THIO AND DITHIO ANALOGUES, THE SALTS THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE AND METHOD FOR THE PRODUCTION THEREOF | Boehringer Ingelheim Pharma KG (DE) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999029662-A2 | URETHANES, THIO AND DITHIO ANALOGUES, THE SALTS THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE AND METHOD FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-06-17 | — | — | WO | disclosed |