Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4931617 | 0.83 | SMN1; SMN2 (0.58) | HRH3SMN1; SMN2L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL8084041 | 0.82 | HRH3 (0.53) | HRH3SMN1; SMN2KDM4EKMT2ANPC1 | |
| SCHEMBL4938412 | 0.79 | L3MBTL3 (0.73) | HRH3L3MBTL3L3MBTL1 | |
| SCHEMBL4938482 | 0.79 | NPC1 (0.51) | HRH3SMN1; SMN2L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL4935057 | 0.78 | HRH3 (0.54) | HRH3SMN1; SMN2L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL1647718 | 0.77 | HRH3 (0.61) | HRH3SMN1; SMN2L3MBTL1KDM4EKMT2A | |
| SCHEMBL8726110 | 0.77 | USP28 (0.40) | HRH3SMN1; SMN2L3MBTL3L3MBTL1NPC1 | |
| SCHEMBL15372617 | 0.77 | TPSAB1 (0.44) | HRH3SMN1; SMN2L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL23507625 | 0.77 | L3MBTL3 (0.50) | HRH3L3MBTL3L3MBTL1 | |
| SCHEMBL4939081 | 0.77 | HRH3 (0.53) | HRH3SMN1; SMN2L3MBTL3L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140850-A1 | QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040561-A1 | QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |