SCHEMBL8084167

SCHEMBL8084167

O=C(NCC12CCCC(CC(Cl)C1)C2)c1ccccc1Cl.[CH2]

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 19/20 0.67
HCN4 Q9Y3Q4 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7571529 0.81 P2RX7 (1.00) P2RX7
SCHEMBL7966259 0.81 P2RX7 (0.72) P2RX7HCN4
SCHEMBL14160599 0.75 P2RX7 (0.48) P2RX7
SCHEMBL7517360 0.75 P2RX7 (0.72) P2RX7
SCHEMBL7570164 0.74 P2RX7 (0.77) P2RX7
SCHEMBL8086064 0.74 P2RX7 (0.73) P2RX7
SCHEMBL7690936 0.74 P2RX7 (0.73) P2RX7
SCHEMBL6497265 0.74 P2RX7 (0.56) P2RX7
SCHEMBL4095273 0.74 P2RX7 (0.56) P2RX7
SCHEMBL8080894 0.74 P2RX7 (0.56) P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1036059-A1 ADAMANTANE DERIVATIVES AstraZeneca UK Limited (GB) 2000-09-20 EP disclosed
WO-1999029661-A1 ADAMANTANE DERIVATIVES ASTRAZENECA UK LIMITED (GB) 1999-06-17 WO disclosed