Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8818678 | 0.85 | DYRK3 (0.48) | DHODHNR1I3PTGESNPC1RAB9A | |
| SCHEMBL8819001 | 0.84 | CHEK2 (0.44) | DHODHNR1I3PTGESNPC1RAB9A | |
| SCHEMBL8891323 | 0.83 | DHODH (0.42) | DHODHNR1I3PTGESNPC1RAB9A | |
| SCHEMBL8818920 | 0.83 | DHODH (0.42) | DHODHNR1I3PTGESNPC1RAB9A | |
| SCHEMBL8816926 | 0.81 | ACHE (0.41) | DHODHNR1I3PTGESNPC1RAB9A | |
| SCHEMBL8082476 | 0.81 | ACHE (0.49) | DHODHNR1I3PTGESNPC1RAB9A | |
| SCHEMBL8817561 | 0.80 | PPARG (0.40) | DHODHNR1I3PTGESNPC1RAB9A | |
| SCHEMBL8818782 | 0.78 | KDM4E (0.35) | DHODHNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8814893 | 0.78 | ACHE (0.51) | DHODHPARP1 | |
| SCHEMBL8816605 | 0.78 | ACHE (0.52) | DHODHL3MBTL1KDM4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2000506529-A | — | — | 2000-05-30 | — | — | JP | claimed |
| WO-1997033873-A1 | METHODS OF TREATING OR PREVENTING INTERSTITIAL CYSTITIS | ELI LILLY AND COMPANY (US) | 1997-09-18 | — | — | WO | claimed |
| WO-1997033873-A1 | METHODS OF TREATING OR PREVENTING INTERSTITIAL CYSTITIS | ELI LILLY AND COMPANY (US) | 1997-09-18 | — | — | WO | disclosed |
| WO-1997031635-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |