Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8077027 | 0.91 | ALDH1A1 (0.36) | ABCC9AKR1B1MEN1KMT2AALDH1A1 | |
| SCHEMBL8174422 | 0.88 | HIF1A (0.34) | ABCC9AKR1B1MEN1KMT2AALDH1A1 | |
| SCHEMBL8076915 | 0.88 | ALDH1A1 (0.34) | ABCC9AKR1B1MEN1KMT2AALDH1A1 | |
| SCHEMBL8088875 | 0.86 | ABCC9 (0.34) | ABCC9AKR1B1MEN1KMT2AALDH1A1 | |
| SCHEMBL8090050 | 0.86 | MEN1 (0.39) | ABCC9AKR1B1MEN1KMT2AALDH1A1 | |
| SCHEMBL8090465 | 0.85 | MAPT (0.34) | ABCC9AKR1B1MEN1KMT2AALDH1A1 | |
| SCHEMBL8088428 | 0.84 | SMN1; SMN2 (0.40) | MEN1KMT2AALDH1A1CYP3A4TDP1 | |
| SCHEMBL8084249 | 0.83 | HIF1A (0.35) | ABCC9AKR1B1MEN1KMT2AALDH1A1 | |
| SCHEMBL8084634 | 0.81 | ABCC9 (0.40) | ABCC9LMNA | |
| SCHEMBL8088701 | 0.81 | ABCC9 (0.47) | ABCC9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |