Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 9/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274240 | 0.83 | ABCC9 (0.62) | ABCC9KDM4EABCB1CYP3A4ALOX15 | |
| SCHEMBL7326444 | 0.80 | ABCC9 (0.39) | ABCC9KDM4EABCB1CYP3A4ALOX15 | |
| SCHEMBL7323149 | 0.80 | ABCC9 (0.56) | ABCC9KDM4EABCB1CYP3A4KCNE1 | |
| SCHEMBL7360393 | 0.80 | ABCC9 (0.58) | ABCC9KDM4EABCB1CYP3A4KCNE1 | |
| SCHEMBL7323543 | 0.80 | ABCC9 (0.58) | ABCC9KDM4EABCB1CYP3A4KCNE1 | |
| SCHEMBL7330073 | 0.79 | ABCC9 (0.59) | ABCC9KDM4EABCB1CYP3A4KCNE1 | |
| SCHEMBL7331034 | 0.78 | ABCC9 (0.56) | ABCC9KDM4EABCB1CYP3A4KCNE1 | |
| SCHEMBL8084323 | 0.78 | ABCC9 (0.56) | ABCC9KDM4EABCB1CYP3A4KCNE1 | |
| SCHEMBL7330523 | 0.78 | ABCC9 (0.56) | ABCC9KDM4EABCB1CYP3A4KCNE1 | |
| SCHEMBL8088840 | 0.78 | ABCC9 (0.56) | ABCC9KDM4EABCB1CYP3A4KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |