Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | EDNRB | P24530 | 5/20 | 0.40 |
| ▸ | EDNRA | P25101 | 5/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085156 | 0.94 | ALOX5 (0.44) | ALOX5EDNRBEDNRAPARP1ALDH1A1 | |
| SCHEMBL8072357 | 0.90 | ALOX5 (0.44) | ALOX5EDNRBEDNRAPARP1ALDH1A1 | |
| Dimethylamine SCHEMBL8072362 | 0.90 | ALOX5 (0.45) | ALOX5EDNRBEDNRAPARP1ALDH1A1 | |
| SCHEMBL8080610 | 0.87 | ALOX5 (0.50) | ALOX5EDNRBEDNRAALDH1A1MAPT | |
| SCHEMBL8085135 | 0.85 | ALOX5 (0.47) | ALOX5EDNRBEDNRAALDH1A1MAPT | |
| SCHEMBL8080604 | 0.83 | ALOX5 (0.50) | ALOX5ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8084922 | 0.82 | ALOX5 (0.53) | ALOX5ALDH1A1MAPTMEN1KMT2A | |
| Dimethylamine SCHEMBL8081518 | 0.81 | ALOX5 (0.47) | ALOX5ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8082048 | 0.79 | MEN1 (0.39) | ALOX5EDNRBEDNRAPARP1ALDH1A1 | |
| SCHEMBL8081513 | 0.77 | ALOX5 (0.46) | ALOX5ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |
| EP-0920416-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998007705-A1 | NAPHTHOLACTAMS AND LACTONES AS BONE MORPHOGENETIC PROTEIN ACTIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-26 | — | — | WO | disclosed |